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1 edition of Toxicity of ethylene oxide and its relevance to man. found in the catalog.

Toxicity of ethylene oxide and its relevance to man.

Toxicity of ethylene oxide and its relevance to man.

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Published by European Chemical Industry Ecology & Toxicology Centre in Brussels .
Written in English

    Subjects:
  • Ethylene compounds -- Safety measures.,
  • Ethylene compounds -- Toxicology.

  • Edition Notes

    Bibliography: p. 63-73.

    SeriesTechnical report / ECETOC -- no. 5, Technical report (European Chemical Industry Ecology & Toxicology Centre) -- no. 5.
    ContributionsEuropean Chemical Industry Ecology & Toxicology Centre
    Classifications
    LC ClassificationsRA1242E72 T69 1982
    The Physical Object
    Paginationii, 75 p. :
    Number of Pages75
    ID Numbers
    Open LibraryOL14258853M

    The Ethylene Oxide Product Stewardship Guidance Manual was prepared by the American Chemistry Council’s Ethylene Oxide/Ethylene Glycols Panel (Panel). It is intended to provide general information to persons who may handle or store ethylene oxide. It is not intended to serve as a . Learn ethylene oxide with free interactive flashcards. Choose from 14 different sets of ethylene oxide flashcards on Quizlet. Chemical name:ethylene oxide Supplier's details: Ethylene Oxide Product use:Synthetic/Analytical chemistry. Airgas USA, LLC and its affiliates North Radnor-Chester Road Suite Radnor, PA SDS # Synonym:oxirane; Oxirane (ethylene oxide) Section 2. Hazards identification FLAMMABLE GASES File Size: KB. The plant is one of dozens around the country that uses a highly toxic carcinogen, ethylene oxide, to sterilize medical equipment. 4% of the total U.S. capacity for Ethylene Oxide.

    Ethylene oxide definition is - a colorless flammable toxic compound C2H4O used especially in synthesis (as of ethylene glycol) and in sterilization and fumigation.


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Toxicity of ethylene oxide and its relevance to man. Download PDF EPUB FB2

Med Lav. Jul-Aug;75(4) [Toxicity of ethylene oxide and its importance for man]. [Article in Italian] Sarto F. PMID: Cited by: 1. ON MAN. Inhalation of the vapour. Toxicity of ethylene oxide and its relevance to man. book A concentration of 1: ethylene oxide was put up in a small chamber and breathed by four subjects.

It had a not unpleasant acetic acid-like smell and was slightly irritant to the nasal passages, but produced no after-effects. Breathed in a concentration of 1: 80, the compound has a definite irritating.

Toxicity of ethylene oxide and its importance for man (PMID) Abstract Citations; Related Articles; Data; BioEntities; External Links ' ' Sarto F La Medicina del Lavoro [01 Jul75(4)] Type: Research Support, Non-U.S. Gov't, Journal Article, English Cited by: 1.

The systemic toxicity of the ethylene-based glycol ethers is mediated by their metabolism to the corresponding alkoxyacetic acids. Methyl- and ethyl-substituted ethylene glycol ethers can cause bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals.

In this paper some of the physical and chemical properties of ethylene oxide are described and also its preparation and its use in the synthesis of organic compounds. It is frequently employed in industry, for example in the manufacture of certain detergents and synthetic perfumes, as a disinfectant of cereals and of dates, and as a : M.

Marchand, R. Deiesvaux, C. Claeys, F. Lejeune. ECETOC () Toxicity of ethylene oxide and its relevance to man, Technical Report No. European Chemical Industry Ecology and Toxicology Toxicity of ethylene oxide and its relevance to man. book, Avenue LouiseBrussels.

Ehrenberg, L., K.D. Hiesche, S. Osterman-Golkar and I. Wennberg () Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide, Mutation Res., 24, 83 Cited by: Ethylene Oxide.

Hazard Summary. The major use of ethylene oxide is as a chemical intermediate in the manufacture of ethylene glycol. Ethylene oxide is also used as a sterilizing agent for medical equipment and a fumigating agent for spices.

The acute (short-term) effects of ethylene oxide in humans consist mainly of central nervous. The database for ethylene oxide is very large; humans and experimental animal studies on acute toxicity, developmental and reproductive toxicity, genetic toxicity (somatic and germ cells), carcinogenicity, and pharmacokinetics and metabolism were available.

These data were used to derive the AEGL values. Ethylene oxide is already known to be a very toxic chemical. It is one of the 33 most hazardous air pollutants identified by EPA as posing the greatest human health risk in.

The use of ETO evolved when few alternatives existed for sterilizing heat- and moisture-sensitive medical devices; however, favorable properties (Table 6) account for its continued widespread use.

Two Toxicity of ethylene oxide and its relevance to man. book gas mixtures are available to replace ETO-chlorofluorocarbon (CFC) mixtures for large capacity, tank-supplied sterilizers.

The ETO-carbon dioxide (CO 2) mixture consists of %. Ethylene oxide, called oxirane by IUPAC, is an organic compound with the formula C 2 H 4 is a cyclic ether and the simplest epoxide: a three-membered ring consisting of one oxygen atom and two carbon ne oxide is a colorless and flammable gas with a faintly sweet odor.

Because it is a strained ring, ethylene oxide easily participates in a number of addition reactions that Chemical formula: C₂H₄O. Introduction. Ethylene Oxide (EtO) is a colorless, flammable gas that smells like ether at toxic levels. EtO is workable gas for many industrial and commercial purposes as intermediate, fumigant and sterilant of medical equipment’s.

Summary: Ethylene oxide is a flammable gas with a somewhat sweet odor. It dissolves easily in water. It dissolves easily in water. Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol Toxicity of ethylene oxide and its relevance to man.

book chemical used to make antifreeze and polyester). PEG owes its widespread use to a combination of low toxicity [6] and 'stealth' character, which can be summarized as a prolonged circulation in body fluids and reduced clearance, as a result of negligible protein adsorption (opsonization) [4,7] and low activation of immune system components [8].

Occupational exposure to ethylene oxide in women sterilising staff working in Gauteng province, South Africa: exposure assessment and association with adverse reproductive outcome.

Presented at the Annual Research Day, School of Public Health, the University. Toxicity of ethylene oxide and its relevance to man. European Chemical Industry Ecology & Toxicology Centre, Ave.

LouiseBruxelles Google Scholar Ehrenberg L, Hiesche KD, Osterman-Golkar S, Wennberg I () Evaluation of genetic risks of alkylating by: Ethylene oxide is toxic and has a long-term maximum exposure limit of 5 ppm. The odor of pure ethylene oxide is not detectable by many people below about ppm, and while impurities present in the industrial material reduce the odor threshold considerably, odor is not a reliable guide to its presence, and artificial means are necessary.

Revised IDLH: ppm [Unchanged] Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Clayton and Clayton ; NRC ; Walker and Greeson ] the original IDLH for ethylene oxide ( ppm) is not being revised at this time.

[Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for ethylene oxide at. The authors describe detailed experiments designed to investigate the chronic toxicity of ethylene oxide. The oxide was fed to laboratory animals by intubation as a 10 per cent.

solution in olive oil, applied to the skin in 10 or 50 per cent. aqueous solution, and administered as the vapour in chronic inhalation experiments. Repeated oral doses of gm. per kgm. over 30 days caused no toxic Cited by: Toxicity of ethylene oxide and its relevance to man.

European Chemical Industry Ecology & Toxicology Centre, Ave. LouiseBruxelles Google Scholar Filser JG, Bolt HM () Pharmacokinetics of halogenated ethylenes in by: As a part of the chemical industry’s responsible management of its products, the Ethylene Oxide Panel Ethylene Oxide Safety Task Group (STG), a group comprised of producers and industrial users, developed the Ethylene Oxide Product Stewardship Manual – 3rd edition.

Ethylene oxide is the smallest of the oxirane family of molecules. It is a sweet-smelling, colorless gas that has many uses; but its high reactivity presents many hazards.

Back inA. Wurtz treated ethylene chlorohydrin with potassium hydroxide to make ethylene oxide and potassium chloride. Ethylene oxide can cause a wide variety of harmful health effects in exposed persons.

In general, with higher levels of exposure to this chemical, more severe effects will occur. The major effects seen in workers exposed to ethylene oxide at low levels for several months or years are irritation of the eyes, skin, and mucous membranes and.

Hazard Assessment Report Ver. 36 ethylene oxide. Judging from its octanol water partition coefficient (log Kow), steam pressure and water solubility (See Chapter 3), it can be assumed that ethylene oxide does not tend to be Table shows the results of toxicity tests of ethylene oxide for invertebrate Size: KB.

Ethylene oxide. National Institute for Occupational Safety and Health (NIOSH), (May ). Provides an Immediately Dangerous to Life or Health document that includes acute toxicity data for ethylene oxide. TOXNET for Ethylene Oxide. The National Library of Medicine Hazardous Substance Database.

Report on Carcinogens (RoC). U.S. Department of. A model of the ethylene oxide molecule. At room temperature, ethylene oxide is a flammable colorless gas with a sweet odor.

It is used primarily to produce other chemicals, including antifreeze. In smaller amounts, ethylene oxide is used as a pesticide and a sterilizing agent. The ability of ethylene oxide to damage DNA makes it an effective.

Ethylene oxide was first produced in the United States in Untilit was produced by the chlorohydrin process, in which ethyl-ene was treated with hypochlorous acid to produce ethylene chlo-rohydrin, and calcium hydroxide or sodium hydroxide was used to convert ethylene chlorohydrin to ethylene oxide.

Essentially all Size: KB. Ethylene glycol (EG; CAS RN ) and its related oligomers include mono- di- tri- tetra- and penta-EG. All of the EGs are quickly and extensively absorbed following ingestion and.

Ethylene oxide has a molecular formula of C2H4O. It is a colorless, flammable gas at ambient temperature and pressure condensing to a liquid below 12°C. It is highly soluble in water and many organic solvents. Liquid ethylene oxide is miscible wit.

Toxicity of methanol,ethanol ethylene glycol 1. TOXICITY OF METHANOL,ETHANOL ETHYLENE GLYCOL: Shivam Patel 2. ALCOHOL Alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a saturated carbon atom. General Formula:CnH2n+1OH.

Ball and stick model of the hydroxyl (-OH) functional group in an alcohol molecule (R3COH). The three. Under the authority of the Federal Advisory Committee Act (FACA) P.L.

ofthe National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review and interpret relevant toxicologic and other scientific data and develop AEGLs for high-priority, acutely toxic chemicals.

Ethylene oxide is commonly used in medical sterilization, it would be nice if a little info on its use and process for this type sterilization was included. —Preceding unsigned comment added by (talk)1 July (UTC). Global production of ethylene was about million tonnes in and is forecast to grow by 4% per year up to Important major industrial reactions involving ethylene are in order of importance (a) polymerization (b) oxidation (c) halogenation and (d) alkylation.

About 60% of ethylene goes to making polyethylene (PE). Product Safety Assessment: Diethylene Glycol Butyl Ether Revised: Decem The Dow Chemical Company Page 5of 11 Ecological and Toxicological Data of DOW Glycol Ethers, Form No.

12 “The Toxicology of Glycol Ethers and Its Relevance to Man,” European Centre for Ecotoxicology and Toxicology of Chemicals, Vol. II – Substance Profiles, Technical Report No. Ethylene oxide vapor has a wide flammability range in air.

Vapor-air mixtures will ignite when exposed to relatively low levels of energy.4 See Physical Hazard Information. Releases of EO liquid or vapor do not persist in the environment. Ethylene oxide has low to moderate aquatic toxicity and will not bioconcentrate (accumulate in the food chain).

Ethylene glycol is a colorless, odorless, sweet liquid, commonly found in antifreeze. It may be drunk accidentally or intentionally in an attempt to cause death. When broken down by the body it results in glycolic acid and oxalic acid which cause most of the toxicity.

The diagnosis may be suspected when calcium oxalate crystals are seen in the urine or when acidosis or an increased osmol gap Causes: Drinking ethylene glycol. Ethylene oxide is a flammable gas with a somewhat sweet odor. It dissolves easily in ne oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester).

A small amount (less than 1%) is used to control insects in some stored agricultural products and a very small amount is used in hospitals to sterilize medical. In Augustthe Agency for Toxic Substance and Disease Registry, a federal agency within the U.S.

Department of Health and Human Services, monitored ethylene oxide levels of. Opinion on the results of the Risk Assessment of: METHYL OXIRANE (PROPYLENE OXIDE) - Human health and Environment - CAS N°: - EINECS N°: Report version: Final Version, 20 February June carried out in the framework of Council Regulation (EEC) /93 on the evaluation and control of the risks of existing substances1.

Use of ethylene oxide alarm systems with sensors. (Decem ). Requirements under the Ethylene Oxide Standards. (Ma ). Procedures for ethylene oxide (EtO) spills and ethylene oxide disposal. (Octo ).

Ethylene glycol, the predominant constituent of automotive products pdf as antifreeze and deicers, is an important but uncommon toxicological problem in current medical practice ()().Individuals intentionally consume ethylene glycol, usually in the form of antifreeze, as an inexpensive alcohol substitute or as a suicidal by:   Both measured well above the national average of micrograms of ethylene oxide per cubic meter.

Ethylene oxide is an industrial compound most commonly used to .Ethylene oxide (which is used to make antifreeze and pesticides) ebook normally handled under pressure ebook a liquid, but at ambient conditions it is a gas that is heavier than air.

Its boiling temperature under atmospheric conditions is 10°C (50°F) and may polymerize exothermically, or join to form larger molecules, if heated or contaminated.